# Ketamine for Treatment-Resistant Depression > Ketamine for treatment-resistant depression on Long Island: how infusions work, who they suit, the research, safety, insurance and what to expect. - Type: informational - URL: https://zenintegrativecare.com/ketamine-treatment-depression/ - Updated: 2026-08-29T01:16:58+00:00 ## About this page Ketamine for treatment-resistant depression on Long Island: how infusions work, who they suit, the research, safety, insurance and what to expect. ## Key facts - Phone: +1 (516) 610-0604 - Email: info@zenintegrativecare.com - Location: Carle Place, NY - Serving: Long Island, NY · New York City, NY · Nassau County, NY · Suffolk County, NY - Logo: /storage/projects/30/files/assets/852c08b1aec16f9a.webp ## Page content ## Ketamine for Treatment-Resistant Depression on Long Island: A Modern Approach Please note: We do not accept Medicaid or Medicaid managed-care plans. For many residents across Nassau and Suffolk Counties, the weight of chronic depression can feel insurmountable. When traditional frontline treatments like Selective Serotonin Reuptake Inhibitors (SSRIs) or cognitive behavioral therapy fail to provide relief, patients are often diagnosed with Treatment-Resistant… ## How It Works Standard antidepressants primarily target monoamines in the brain, such as serotonin, norepinephrine, and dopamine. However, researchers believe that for many with TRD, the issue lies within the glutamate system, which is the brain's most abundant chemical messenger. Ketamine acts as an NMDA (N-methyl-D-aspartate)… Beyond its immediate chemical impact, ketamine promotes neuroplasticity. Chronic depression often leads to the shrinking of dendrites—the branches of neurons that facilitate communication between brain cells. Ketamine helps to rebuild these structures, allowing the brain to become more adaptable and responsive to… ## Who Is This Treatment For? Ketamine therapy is specifically geared toward individuals who have not found success with standard psychiatric interventions. It is intended for those who are currently under the care of a mental health professional but require a more robust biological intervention to overcome the barriers of TRD. Ideal candidates… Patients with Treatment-Resistant Depression: Individuals who have tried at least two different classes of antidepressants without achieving remission. ## What the Research Says The evidence base for ketamine as a rapid-acting antidepressant has grown significantly over the last two decades. Institutions such as Yale University, the National Institute of Mental Health (NIMH), and Johns Hopkins have conducted extensive clinical trials exploring its efficacy. Research suggests that ketamine can… Furthermore, long-term observational studies indicate that when ketamine is used as part of a comprehensive treatment plan, the improvements in mood can be sustained through maintenance sessions. The medical community recognizes ketamine's ability to reduce the "noise" of depressive thinking, providing a "biological… ## What to Expect at Our Clinic Your journey begins with an in-depth clinical consultation. During this meeting, our medical team reviews your psychiatric history, current medications, and physical health to ensure ketamine is a safe and appropriate option for you. We serve patients across Nassau and Suffolk Counties, providing a convenient home… ## Related - [Ketamine for Anxiety Disorders](https://zenintegrativecare.com/ketamine-for-anxiety/) - [Ketamine for PTSD](https://zenintegrativecare.com/ketamine-for-ptsd/) - [Ketamine for Mental Health](https://zenintegrativecare.com/ketamine-for-mental-health/) - [Ketamine Infusion Therapy](https://zenintegrativecare.com/ketamine-infusion-therapy/) - [Ketamine Assisted Psychotherapy (KAP)](https://zenintegrativecare.com/services/ketamine/ketamine-assisted-psychotherapy-kap/)